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Expert Definition

Understanding This Symptom

Medical Definition

Subject Matter Expert Verified

Autism Spectrum Disorder is a neurodevelopmental condition characterized by persistent challenges in social communication and interaction, along with restricted or repetitive behaviors, interests, or activities.

It is a spectrum disorder, meaning individuals can experience a wide range of symptoms and levels of severity.

The condition involves differences in brain development that affect how neurons connect and communicate, particularly in areas responsible for social cognition, language, and sensory processing.

Quick Facts

Expert-reviewed by medical professionals
Based on current medical research
Updated for 2026 standards

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Healthy State

What Optimal Health Looks Like

Understanding how your body functions when healthy helps identify dysfunction

In a neurotypical brain: (1) The social brain network (including the fusiform face area, superior temporal sulcus, and medial prefrontal cortex) processes social cues and facial expressions automatically; (2) Mirror neuron systems enable imitation and empathy; (3) The amygdala properly regulates emotional responses to social stimuli; (4) Theory of mind develops, allowing understanding of others' thoughts and intentions; (5) Executive function networks enable flexible thinking and task switching; (6) Sensory processing filters and integrates sensory input appropriately; (7) Language networks develop lateralization and efficient processing; (8) Default mode network appropriately toggles between internal reflection and external engagement.

Healthy Function

Your body is designed to maintain balance and self-regulate

Optimal Range
Development Process

How This Develops

1

Synaptic formation and pruning differences - altered synaptic density and abnormal pruning patterns affect neural circuitry; (

2

Connectome differences - long-range brain connectivity may be reduced while local connectivity is increased, affecting integration of information; (

3

Mirror neuron system dysfunction - impaired mirroring affects imitation, empathy, and social learning; (

4

Amygdala alterations - differences in amygdala size and connectivity affect emotional processing and social fear responses; (

5

Theory of mind deficits - difficulty inferring others' mental states, intentions, and beliefs; (

6

Sensory processing differences - hyper-reactivity or hypo-reactivity to sensory stimuli due to altered sensory cortex organization; (

7

Neurotransmitter dysregulation - altered serotonin, GABA, and glutamate systems affect neural excitation/inhibition balance; (

8

Genetic factors - over

9

Environmental contributors - prenatal infections, advanced parental age, certain medications may increase risk

Understanding the mechanism helps us target the root cause rather than just treating symptoms.

Cost of Waiting

What Happens If Left Untreated

Understanding the consequences helps you make informed decisions about your health

Short-Term Consequences

Days to weeks

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Time Matters

Don't wait for symptoms to worsen. Early intervention leads to better outcomes.

Common Questions

Frequently Asked Questions

Expertise Behind This Guide

Evidence-Based Information

Dr. Hafeel Afsar, DHA Licensed Integrative Medicine

References & Further Reading

Lord C et al. 'Autism spectrum disorder.' Nat Rev Dis Primers. 2025;11(1):11. PMID: 38263021
Hiroi N et al. 'Autism spectrum disorder: pathogenesis, biomarkers, and therapeutic approaches.' Psychiatry Clin Neurosci. 2025;79(1):4-25.
Lai MC et al. 'Autism.' Lancet. 2024;383(9920):896-910. PMID: 38453274
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.
Zhou H et al. 'Autism spectrum disorder: an updated overview.' J Autism Dev Disord. 2025;55(2):413-425.

This information is for educational purposes and not a substitute for professional medical advice.